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Have also kept up with this forum due to family members addictions. Other drugs may interact with methadone, including prescription and over-the-counter medicines, vitamins, and herbal products. It also carries the risk of being habit forming. ...Methadone, sold under the brand name Dolophine among others, is an opioid used to treat pain and as maintenance therapy or to help with tapering in people with opioid dependence.[3] Detoxification using methadone can either be done relatively rapidly in less than a month or gradually over as long as six months.[3] While a single dose has a rapid effect, maximum effect can take five days of use.[3] The pain relieving effects last about six hours after a single dose, similar to that of morphine.[3][5] After long term use, in people with normal liver function, effects last 8 to 36 hours.[3][4] Methadone is usually taken by mouth and rarely by injection into a muscle or vein.[3] Side effects are similar to those of other opioids.[3] Commonly these include dizziness, sleepiness, vomiting, and sweating.[3] Serious risks include opioid abuse and a decreased effort to breathe.[3] Abnormal heart rhythms may also occur due to a prolonged QT interval.[3] The number of deaths in the United States involving methadone poisoning declined from 4,418 in 2011[6] to 3,300 in 2015.[7] Risks are greater with higher doses.[8] Methadone is made by chemical synthesis and acts on opioid receptors.[3] Methadone was developed in Germany around 1937 to 1939 by Gustav Ehrhart and Max Bockmühl.[9][10] It was approved for use in the United States in 1947.[3] Methadone is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[11] Globally in 2013, about 41,400 kilograms were manufactured.[12] It is regulated similarly to other narcotic drugs.[13] It is not particularly expensive in the United States.[14] Contents Medical uses[edit] Methadone maintenance[edit] Methadone is used for the treatment of opioid dependency. Dosage adjustment using higher doses or administering the daily dose in divided doses may be necessary in pregnant women treated with methadone. (See CLINICAL PHARMACOLOGY and DOSAGE AND ADMINISTRATION).

If opioid use is required for a prolonged period in a pregnant woman, advise the patient of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available. People who metabolize methadone rapidly, on the other hand, may require twice daily dosing to obtain sufficient symptom alleviation while avoiding excessive peaks and troughs in their blood concentrations and associated effects.[50] This can also allow lower total doses in some such people. CMP's excessive rate of involuntary withdrawals was also pinned on violent behaviour and abuse towards staff, pharmacists or other clients - a phenomenon that had increased in the post-earthquake environment, the CDHB said. Oxycodone (Oxycontin, Percocet) 10mg..............

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Next time respect and listen to your doctors instructions with regards to these highly regulated and very dangerous medications. ... Would you like to make it the primary and merge this question into it? Methadone hydrochloride is chemically described as 6-(dimethylamino)-4,4-diphenyl-3-hepatanone hydrochloride. 07(c)), to facilitate the treatment of the primary admitting diagnosis. Also, sugar-free gum increases the amount of saliva in the mouth and can counteract the dryness that is sometimes caused by methadone.

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How do you get methadone? you must visit a doctor who will assess weather or not you are eligible for methadone program. It does have a tolerance though, used to be 1 or 2 would get me messed, now I take 4 and not really feel a thing. If you are having swallowing difficulties, this may be related to serious esophageal disease, and you need to talk to the prescribing doctor and/or your primary care physician.

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As a person’s dependency & tolerance to opioids builds over time, they find that they need greater amounts of opioids or stronger opioids in order to eliminate their withdrawal symptoms.    So How Does The Clinic Determine How Much Methadone I Need? Hypotensive Effect The administration of methadone may result in severe hypotension in patients whose ability to maintain normal blood pressure is compromised (e.g., severe volume depletion). Such opioid rotation is standard practice for managing people with tolerance development. Methadone is almost as effective when administered orally as by injection. Keep the medication in a place where others cannot get to it. A 2013 study in BMC Psychiatry looked at people using methadone maintenance treatment to combat heroin addiction in Taiwan and found that, for every six-month period they participated in the treatment, their psychological state and overall quality of life increased.

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