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A medical examination is given prior to administration of the methadone, and new patients are often tested for certain conditions which are known to be prevalent in addict populations, such as HIV, hepatitis, and tuberculosis. Methadone can be used either as a pain reliever or as part of drug addiction detoxification and maintenance programs. Methadone also is used to reduce withdrawal symptoms in people addicted to heroin or other narcotic drugs without causing the "high" associated with the drug addiction. For additional information: www.fda.gov/REMS US BOXED WARNINGS: ADDICTION, ABUSE, and MISUSE: This drug exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Methadone also acted as a potent, noncompetitive α3β4 neuronal nicotinic acetylcholine receptor antagonist in rat receptors, expressed in human embryonic kidney cell lines.[45] [edit] Methadone has a slow metabolism and very high fat solubility, making it longer lasting than morphine-based drugs.

Special-Risk Patients Methadone should be given with caution, and the initial dose reduced, in certain patients such as the elderly and debilitated, and those with severe impairment of hepatic or renal function, hypothyroidism, Addison's disease, prostatic hypertrophy, or urethral stricture. Never use methadone tablets or liquid to make a mixture for injecting the drug into your vein.

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Other adverse reactions include the following: (listed alphabetically under each subsection) Body as a Whole: asthenia (weakness), edema, headache Cardiovascular:(also see WARNINGS: Cardiac Conduction Effects): arrhythmias, bigeminal rhythms, bradycardia, cardiomyopathy, ECG abnormalities, extrasystoles, flushing, heart failure, hypotension, palpitations, phlebitis, QT interval prolongation, syncope, T-wave inversion, tachycardia, torsade de pointes, ventricular fibrillation, ventricular tachycardia Digestive: abdominal pain, anorexia, biliary tract spasm, constipation, dry mouth, glossitis Hematologic and Lymphatic: reversible thrombocytopenia has been described in opioid addicts with chronic hepatitis Metabolic and Nutritional: hypokalemia, hypomagnesemia, weight gain Nervous: agitation, confusion, disorientation, dysphoria, euphoria, insomnia, seizures Respiratory: pulmonary edema, respiratory depression (see WARNINGS: Respiratory Depression) Skin and Appendages: pruritis, urticaria, other skin rashes, and rarely, hemorrhagic urticaria Special Senses: hallucinations, visual disturbances Urogenital: amenorrhea, antidiuretic effect, reduced libido and/or potency, urinary retention or hesitancy Maintenance on a Stabilized Dose During prolonged administration of methadone, as in a methadone maintenance treatment program, there is usually a gradual, yet progressive, disappearance of side effects over a period of several weeks. Ultimately, every day lived in recovery is a benefit, reducing the negative effects of opioid addiction.

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If you don't wont to be free completely from opiates and prefer tolive under their influence, 40 mg of metha will procure sleep andhot skin for a long period of years without big risk (but thissituation will make you lifeless, sexually uninterested and alwaystoo tired for a living normal, since the metha is the worstnarcotic ever invented). sorry for the bad English, im a italianmafiosetto... A: Methadone is in a drug class called opiate or narcotic analgesics. A longer half-life frequently allows for administration only once a day in Opioid detoxification and maintenance programs. Methadone is an opioid agonist, which means it binds to the opioid receptors in the brain and activates them, leading to pain relief. Cardiac Conduction Effects This information is intended to alert the prescriber to comprehensively evaluate the risks and benefits of methadone treatment.

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S. federal regulations require the oral form in addiction treatment programs.[54] Information leaflets included in packs of UK methadone tablets state that the tablets are for oral use only and that use by any other route can cause serious harm. A medical examination is given prior to administration of the methadone, and new patients are often tested for certain conditions which are known to be prevalent in addict populations, such as HIV, hepatitis, and tuberculosis. Contents Regulation and policy[edit] In the United States, there are generally two types of methadone clinics, public and private. Under the conditions of the assay, there was no clear evidence for a treatment-related increase in the incidence of neoplasms in male rats. There was a significant increase in pituitary adenomas in female mice treated with 15 mg/kg/day but not with 60 mg/kg/day. 12, including limitations on unsupervised administration. As a person’s dependency & tolerance to opioids builds over time, they find that they need greater amounts of opioids or stronger opioids in order to eliminate their withdrawal symptoms.    So How Does The Clinic Determine How Much Methadone I Need? Do not take more medication or abruptly stop a medication without first consulting with the healthcare provider. Everyone reacts/responds differently to medication and to addiction, so your doctor and answer your question to this best. When using naloxone, the naloxone will be quickly eliminated and the withdrawal will be short lived. MISUSE OF THIS MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Many people receive this treatment through a methadone clinic or rehab facility.

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