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The duration of methadone treatment ranges from a few months to several years, or even lifelong. In an individual physically dependent on opioids, the administration of the usual dose of an opioid antagonist may precipitate an acute withdrawal syndrome. The dextrorotary form (dextromethadone), which acts as an NMDA receptor antagonist and is devoid of opioid activity, has been shown to produce analgesia in experimental models of chronic pain. The severity of the symptoms is directly proportional to the dose and duration of the methadone therapy.

FAILURE TO ABIDE BY THE REQUIREMENTS IN THESE REGULATIONS MAY RESULT IN CRIMINAL PROSECUTION, SEIZURE OF THE DRUG SUPPLY, REVOCATION OF THE PROGRAM APPROVAL, AND INJUNCTION PRECLUDING OPERATION OF THE PROGRAM. If you or a loved one could be struggling with a substance use disorder involving methadone or other drugs, we invite you to contact our compassionate and well-trained team at The Recovery Village. The address of the facility and a map that allows you to see the streets and other buildings of note nearby.

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Most functions for front desk, dispensing and counseling operations are completed in only a few keystrokes. This risk is increased with concurrent abuse of methadone with alcohol and other substances. Ask yourself if you have any friends who live close to one of these facilities.

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I have been taking methadone for over a year now. The Charleston Gazette reported, "The old language about the 'usual adult dose' was potentially deadly, according to pain specialists."[43] Pharmacology[edit] Methadone acts by binding to the ยต-opioid receptor, but also has some affinity for the NMDA receptor, an ionotropic glutamate receptor. Methadone is used as a pain reliever and as part of drug addiction detoxification and maintenance programs.

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To date, methadone maintenance therapy has been the most systematically studied and most successful,[citation needed] and most politically polarizing,[citation needed] of any pharmacotherapy for the treatment of people with drug addiction. Read and carefully follow any Instructions for Use provided with your medicine. Avoid driving or operating machinery until you know how this medicine will affect you. Methadone is prescribed for pain and also drug addiction detoxification. Chemically they are the same, however the way your body processes it can affect the strength and how long it will last.

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