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People who metabolize methadone rapidly, on the other hand, may require twice daily dosing to obtain sufficient symptom alleviation while avoiding excessive peaks and troughs in their blood concentrations and associated effects.[50] This can also allow lower total doses in some such people. A 2009 Cochrane review found methadone was effective in retaining people in treatment and in the reduction or cessation of heroin use as measured by self-report and urine/hair analysis but did not affect criminal activity or risk of death.[15] The treatment of opioid-dependent persons with methadone will follow one of two routes.[citation needed] Methadone maintenance therapy (MMT) usually takes place as an outpatient.

There are other mixtures as well that use different syrup bases like Sorbitol syrup or Unpreserved syrup. Nausea, vomiting,: Aggitation, shaking, and diarrhea are all seen in opioid withdrawal including methadone, although due to the long half like of Methadone it is actually less likely with this medication than many of the others. ... If too large a dose of the opioid antagonist is given to a dependent person, it will result in withdrawal symptoms (possibly severe).

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Read More As promised per my PM, I am responding to your post. Taking this medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn. Overdose symptoms may include slow breathing and heart rate, severe drowsiness, muscle weakness, cold and clammy skin, pinpoint pupils, and fainting.

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When your doctor prescribes a new medication, be sure to discuss all your prescription and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals, and herbals, as well as the foods you eat. Besides weakened respiratory and cardiac functions, methadone users may suffer from the following long-term medical conditions or disorders affecting various other major organs and systems of the body: Whole Body: headaches, weakness, and water retention Central Nervous System: confusion, disorientation, euphoria, depression and listlessness, sleep disturbances Endocrinal System: hypogonadism or low testosterone level, a condition that impairs growth and development in males during puberty Gastrointestinal System: abdominal pain, constipation, dry mouth Metabolic System: low potassium or magnesium levels, weight gain Blood: low platelet count that causes the blood to clot slowly after an injury, bruising, internal bleeding Kidneys: urine retention, difficulty urinating Reproductive System: reduced sexual drive, reduced sperm production, abnormal absence of menstruation in women Skin: rashes, hives, severe itching that can lead to sores Not all methadone users exhibit the adverse effects of the drugs to the same degree. Methadone acts on the same brain structures  and processes as addictive opioid drugs do.

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This is not a complete list of side effects that can occur with methadone. Under the conditions of the assay, there was no clear evidence for a treatment-related increase in the incidence of neoplasms in male rats. It is a completely colorless liquid and smells minty-like. ... In general methadone should be gradually discontinued to avoid becoming sick with withdrawal symptoms. In addition to the physical symptoms, a long-term methadone use can affect the brain and impair certain mental processes. Patients who use other substances of abuse should not breastfeed. Myth #1 – Methadone Causes Weight Gain This is a tricky one. Methadone was introduced into the United States in 1947 by Eli Lilly and Company as an analgesic under the trade name Dolophine,[63] which is now registered to Roxane Laboratories. To help you make the most informed decision, MethadoneTreatment.net features information about more than 10,000 methadone treatment centers throughout the United States. This can also help you learn a lot more about a particular clinic and its policies.

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