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Methadone can cause slow or shallow breathing and dangerous changes in heartbeat that may not be felt by the patient." The advisory urged that physicians use caution when prescribing methadone to people who are not used to the drug and that people take the drug exactly as directed.[23] Adverse effects of methadone include:[citation needed] Sedation Diarrhea[24] or constipation[24][25] Flushing[25] Perspiration[25] and sweating[25] Heat intolerance Dizziness[24][26][27] or fainting[24][26][27] Weakness[25] Chronic fatigue, sleepiness[25] and exhaustion Sleep problems such as drowsiness,[24] trouble falling asleep (Insomnia),[25][26] and trouble staying asleep[25] Constricted pupils Dry mouth[24][25] Nausea[24][25] and vomiting[24][25] Low blood pressure Hallucinations[24][26] or confusion[24][26] Headache[25] Heart problems such as chest pain[24][26] or fast/pounding heartbeat[24][26][27] Abnormal heart rhythms[27][28] Respiratory problems such as trouble breathing,[24][26] slow or shallow breathing (hypoventilation),[24][26] light-headedness,[24][26][27] or fainting[24][26] Loss of appetite,[24][25] and in extreme cases anorexia Weight gain[25] Memory loss Stomach pains[25] Itching Difficulty urinating[25] Swelling of the hands, arms, feet, and legs[25] Feeling restless[24] or agitated Mood changes,[25] euphoria, disorientation Nervousness[24] or anxiety[24][26] Blurred vision[25] Decreased libido,[24][25] missed menstrual periods,[25] difficulty in reaching orgasm,[24] or impotence[24][25] Skin rash Seizures Central sleep apnea Withdrawal symptoms[edit] Physical symptoms[citation needed] Lightheadedness[29] Tearing of the eyes[29][30] Mydriasis (dilated pupils)[29] Photophobia (sensitivity to light) Hyperventilation syndrome (breathing that is too fast/deep) Runny nose[30] Yawning Sneezing[30] Nausea,[29][30] vomiting,[29][30] and diarrhea[29] Fever[30] Sweating[29] Chills[30] Tremors[29][30] Akathisia (restlessness) Tachycardia (fast heartbeat)[30] Aches[29] and pains, often in the joints or legs Elevated pain sensitivity Blood pressure that is too high (hypertension, may cause stroke) Cognitive symptoms[citation needed] Suicidal ideation Susceptibility to cravings[29] Depression[29] Spontaneous orgasm Prolonged insomnia Delirium Auditory hallucinations Visual hallucinations Increased perception of odors (olfaction), real or imagined Marked decrease or increase in sex drive Agitation Anxiety[29] Panic disorder Nervousness[29] Paranoia Delusions Apathy Anorexia (symptom) Methadone withdrawal symptoms are reported as being significantly more protracted than withdrawal from opioids with shorter half-lives. In the early days of my methadone clinic, they did give the pills, but they were being snuck out of the distribution booth and sold on the street.

I was 50 and they were treating me like a 5-year-old," she claimed. "They had power over my whole life. Methadone is metabolized by CYP3A4, CYP2B6, CYP2D6 and is a substrate for the P-glycoprotein efflux protein in the intestines and brain. They have conversion charts available on most medical websites.

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If used correctly, methadone can be a very helpful h.r.t. but rarely does it work out that way. Upon discontinuation of phenytoin, the incidence of withdrawal symptoms decreased and methadone exposure increased to a level comparable to that prior to phenytoin administration. If you do not see your city or town specifically, it may be best to choose the one that is closest to you. Get it checked out: You should get it checked out. Now I have been taking meth for 5 years, because I enjoy it.

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The only cases where it should be used is it if it is prescribed by a doctor for harrowing conditions when the doctor believes that the drug is the only suitable drug, or for replacement therapy for opioid treatment. For these reasons, steady-state plasma concentrations, and full analgesic effects, are usually not attained until 3 to 5 days of dosing. The major hazards of methadone are respiratory depression and, to a lesser degree, systemic hypotension. Weight gain can also be a common side effect of methadone. The only time any doctor is obligated to treat you is if you're in life threatening danger.

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Providing you with a medication such as this is not something they have to do. I take urines there once a month....unannounced, of course. Based on information like this, it’s important for supervising physicians to conduct a cost-benefit analysis regarding use of methadone. Methadone is contraindicated in any patient who has or is suspected of having a paralytic ileus. Additional information on the potential risks of methadone may be derived from animal data. 50 per defined daily dose.[78] Brand-name methadone tablets may cost much more. There are numerous factors that influence how a person will respond to varying methadone dosages: the number of years they have been addicted to opioids the type of opioids used and the amount the frequency of use method of use (oral, inhalation, or injection) as well as the person’s general state of health including liver functioning and other factors.

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