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Carcinogenesis, Mutagenesis, Impairment Of Fertility Carcinogenesis The results of carcinogenicity assessment in B6C2F1 mice and Fischer 344 rats following dietary administration of two doses of methadone HCl have been published. Methadone hydrochloride USP is a white, crystalline material that is water-soluble. Note: the oral solution should never be injected directly into the blood stream. It is easy to reduce dosages, and it can be used safely in relatively high doses, which makes it a good option for what's usually called methadone maintenance therapy (MMT).

My friend takes the liquid methadone from the clinic - she said 1 tsp contains 50mg of methadone. Patients are enrolled into a comprehensive program, which includes medication maintenance treatment and individual & group counseling to address psychological and social needs in addition to their chemical dependence.

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A medical examination is given prior to administration of the methadone, and new patients are often tested for certain conditions which are known to be prevalent in addict populations, such as HIV, hepatitis, and tuberculosis. People who metabolize methadone rapidly, on the other hand, may require twice daily dosing to obtain sufficient symptom alleviation while avoiding excessive peaks and troughs in their blood concentrations and associated effects.[50] This can also allow lower total doses in some such people. Research on methadone’s potency, such as a study in Clinical Pharmacology and Therapeutics, has discovered that snorting a powered version of the substance can result in a rapid high with opioid-like effects.

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Compared to other opioids, methadone has a lower cross-tolerance when switching to it from other opioids.[21] This means that methadone can start at a comparatively lower dose than other opiates, and the time for the next switch will be longer. It also carries the risk of being habit forming. ...Methadone, sold under the brand name Dolophine among others, is an opioid used to treat pain and as maintenance therapy or to help with tapering in people with opioid dependence.[3] Detoxification using methadone can either be done relatively rapidly in less than a month or gradually over as long as six months.[3] While a single dose has a rapid effect, maximum effect can take five days of use.[3] The pain relieving effects last about six hours after a single dose, similar to that of morphine.[3][5] After long term use, in people with normal liver function, effects last 8 to 36 hours.[3][4] Methadone is usually taken by mouth and rarely by injection into a muscle or vein.[3] Side effects are similar to those of other opioids.[3] Commonly these include dizziness, sleepiness, vomiting, and sweating.[3] Serious risks include opioid abuse and a decreased effort to breathe.[3] Abnormal heart rhythms may also occur due to a prolonged QT interval.[3] The number of deaths in the United States involving methadone poisoning declined from 4,418 in 2011[6] to 3,300 in 2015.[7] Risks are greater with higher doses.[8] Methadone is made by chemical synthesis and acts on opioid receptors.[3] Methadone was developed in Germany around 1937 to 1939 by Gustav Ehrhart and Max Bockmühl.[9][10] It was approved for use in the United States in 1947.[3] Methadone is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[11] Globally in 2013, about 41,400 kilograms were manufactured.[12] It is regulated similarly to other narcotic drugs.[13] It is not particularly expensive in the United States.[14] Contents Medical uses[edit] Methadone maintenance[edit] Methadone is used for the treatment of opioid dependency. What is more important is when u started vomiting, how long u had it, do u have abdominal pain, fever, headache ...Prescription Drug Abuse Slideshow: Facts and Statistics OTC and Prescription Drug Abuse Slideshow Pictures Health Risks of Alcohol Abuse Slideshow Pictures Drug Description Methadone Hydrochloride Oral Concentrate USP CII, 10 mg per mL (Dye-Free, Sugar-Free, Unflavored) and Methadone Hydrochloride Oral Concentrate USP CII, 10 mg per mL (Cherry) Regulatory Exceptions to the General Requirement for Certification to Provide Opioid Agonist Treatment During inpatient care, when the patient was admitted for any condition other than concurrent opioid addiction (pursuant to 21 CFR 1306. Methadone can also reduce withdrawal symptoms in people addicted to heroin or other narcotic drugs without causing the "high" associated with the drug addiction. If used correctly, methadone can be a very helpful h.r.t. but rarely does it work out that way.

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Once a person has a strong footing in recovery, their doctor may slowly the dose of methadone over time to wean them off the substance. A sudden stop in usage could lead to several withdrawal symptoms. Under the conditions of the assay, there was no clear evidence for a treatmentrelated increase in the incidence of neoplasms in either male or female rats. If this is the case, we recommend disabling these add-ons. As far as the color being lighter, that's because of the water they add. ## Methadone is red taken it for18 year's unfortunately it's one thing that is hell to get off of good luck and I do mean good luck !!!!!! Since methadone often enables those suffering from opioid addiction to live balanced, productive lives in recovery, the benefits are great. So a dose 100 times that, taken by someone not tolerant to it, can actually kill bypassing any "high" or euphoria, will reduce oxygen to brain and other organs, lower heart rate, and depress respiration after taking such a dose. Also, the daily dose, severity of the pain, the patient's degree of opioid tolerance, and age and medical status of the patient should be taken into account. The withdrawal period can be much more prolonged than with other opioids, spanning anywhere from two weeks to several months. When it is time to stop taking this medication, your medical team can lead you through the process so that you are able to deal with the symptoms accordingly.

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