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An overdose of this medicine can be fatal, especially in a child or other person using the medicine without a prescription. Methadone may cause a life-threatening heart rhythm disorder. Methadone works to relieve pain by altering the way in which the brain and nervous system respond to pain. I've also read a lot of medical journals that basically state they'll ween you off hydro but there is the possibility of getting addicted to them. Methadone is not recommended for obstetric analgesia because its long duration of action increases the probability of respiratory depression in the newborn.

They should protect it from theft, and it should never be given to anyone other than the individual for whom it was prescribed. Long-term methadone has few major side effects when used properly, but causes physical dependency (like all opioids), and can reduce both male and female sex hormones, cause constipation, dry mouth/dental issues, sweating, weight gain, and rarely a heart rhythm issue. ... It wasn’t until 1971, however, that the FDA approved methadone as a viable medical treatment for heroin and other narcotic abuse. Methadone acts on the same brain structures  and processes as addictive opioid drugs do. Methadone is used as a pain reliever and as part of drug addiction detoxification and maintenance programs.

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The people at these palces pretend like they are there for you but they are not. Methadone is often administered to treat heroin addiction in pregnant women. What I don't understand is why anybody would even think of changing your medication regime when you seemed to be doing fine for years and years on the same dose!!!

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The focus of these clinics is the elimination or reduction of opioid usage by putting the patient on methadone which is a long acting opioid. Occasional and Preventative Use Methadone should never be used casually or recreationally to get high.

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These animal data mirror the reported clinical findings of decreased testosterone levels in human males on methadone maintenance therapy for opioid addiction and in males receiving chronic intraspinal opioids. Other adverse reactions include the following: (listed alphabetically under each subsection) Body as a Whole: asthenia (weakness), edema, headache Cardiovascular:(also see WARNINGS: Cardiac Conduction Effects): arrhythmias, bigeminal rhythms, bradycardia, cardiomyopathy, ECG abnormalities, extrasystoles, flushing, heart failure, hypotension, palpitations, phlebitis, QT interval prolongation, syncope, T-wave inversion, tachycardia, torsade de pointes, ventricular fibrillation, ventricular tachycardia Digestive: abdominal pain, anorexia, biliary tract spasm, constipation, dry mouth, glossitis Hematologic and Lymphatic: reversible thrombocytopenia has been described in opioid addicts with chronic hepatitis Metabolic and Nutritional: hypokalemia, hypomagnesemia, weight gain Nervous: agitation, confusion, disorientation, dysphoria, euphoria, insomnia, seizures Respiratory: pulmonary edema, respiratory depression (see WARNINGS: Respiratory Depression) Skin and Appendages: pruritis, urticaria, other skin rashes, and rarely, hemorrhagic urticaria Special Senses: hallucinations, visual disturbances Urogenital: amenorrhea, antidiuretic effect, reduced libido and/or potency, urinary retention or hesitancy Maintenance on a Stabilized Dose During prolonged administration of methadone, as in a methadone maintenance treatment program, there is usually a gradual, yet progressive, disappearance of side effects over a period of several weeks. They had me in liquid handcuffs." Marino had also known Dave Longstaffe, whose children believe his involuntary withdrawal from methadone played a role in his death. "They tried to play God with what he needed. The change deleted previous information about the usual adult dosage. I now have plenty nausea, fatigue and usual restlessness on all the opiates. Since I have been taking the liquid I have went from 40mg a day to 100mg a day in just over three months, however I have decreased my dose to 70mg over the past few months because I was worried to be at such a high dose so fast. Under the conditions of the assay, there was no clear evidence for a treatmentrelated increase in the incidence of neoplasms in either male or female rats. The dextrorotary form (dextromethadone), which acts as an NMDA receptor antagonist and is devoid of opioid activity, has been shown to produce analgesia in experimental models of chronic pain. For Short-Term Detoxification For patients preferring a brief course of stabilization followed by a period of medically supervised withdrawal, it is generally recommended that the patient be titrated to a total daily dose of about 40 mg in divided doses to achieve an adequate stabilizing level. However, the positive qualities of methadone don’t always outweigh the short-term and long-term effects of its use. Pharmacokinetics of methadone may be unpredictable when coadministered with drugs that are known to both induce and inhibit CYP enzymes.

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