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Hepatic Impairment Methadone has not been extensively evaluated in patients with hepatic insufficiency. Dose Adjustments Elderly patients: Start at the low end of the dosing range and closely monitor for signs of respiratory and CNS depression. Note: the oral solution should never be injected directly into the blood stream.

There is a new drug out in the market that can be prescribed by a doctor. Keep the medication in a place where others cannot get to it. Read more See 2 more doctor answers Clinics (Definition) Clinics are sites that provide outpatient medical care by appointment or walk-in. ...Overcoming an Opiate Addiction Overcoming an opiate addiction can be a long and difficult process – but it doesn't have to be that way. Often, patients using a maintenance program will want to try to taper off the methadone once their cravings have subsided and other areas of their lives are showing progress. These statistics have drummed up controversy on all sides of the methadone debate. Methadone accumulation may cause the following effects: Respiratory depression that manifests as slow breathing or difficulty breathing Low levels of oxygen in the blood Depression of the central nervous system These symptoms of overdose manifest gradually, making methadone accumulation a potentially fatal side effect in some people.

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The analgesic activity is shorter than the pharmacological half-life; dosing for pain control usually requires multiple doses per day normally dividing daily dosage for administration at 8 hour intervals.[52] The main metabolic pathway involves N-demethylation by CYP3A4 in the liver and intestine to give 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP).[1][53] This inactive product, as well as the inactive 2-ethyl-5-methyl-3,3- diphenyl-1-pyrroline (EMDP), produced by a second N-demethylation, are detectable in the urine of those taking methadone. A heavy-handed culture at the Christchurch Methadone Programme (CMP) is condemning addicts to a world of suicide, accidental overdose, crime and prostitution, according to a damning review.

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To date, methadone maintenance therapy has been the most systematically studied and most successful,[citation needed] and most politically polarizing,[citation needed] of any pharmacotherapy for the treatment of people with drug addiction. Read more 1 doctor agreed: 11 11 My brother goes to the methadone clinic he takes 70 mg of liquid and he has prescription for ativan (lorazepam). The clinic that I am going to in Indiana has both the tablets that they will dissolve in water, or just red cherry flavored liquid methadone. Methadone can also reduce withdrawal symptoms in people addicted to heroin or other narcotic drugs without causing the "high" associated with the drug addiction.

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Let me know if I can be of further assistance. ... Methadone works to relieve pain by altering the way in which the brain and nervous system respond to pain. It is prescribed once or twice daily for those who wish to abstain from illicit drug use. I went off methadone cold turkey from 65 mg and it was hell..in my opinion there is little difference in w/d from 10mg to 65 mg in terms of w/d..others may disagree but I don't care. methadone has a very long 1/2 life..meaning it build itself up in your system.. Suggest to discuss Ativan (lorazepam) with his Psychiatrist ... The Short-Term Effects of Methadone Because methadone is a synthetic opiate, it mimics some of the effects of heroin by acting on the same receiving centers in the brain. Read More Am posting here to see if I can get some help.

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