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Many physicians and OTP hubs are available to provide medical maintenance where up to a month’s supply can be prescribed for those transferring from a formal methadone maintenance program. A high degree of “opioid tolerance” does not eliminate the possibility of methadone overdose, iatrogenic or otherwise.

Assess each patient's risk prior to prescribing, and monitor all patients regularly for the development of these behaviors or conditions. Your doctor or health care provider is best able to guide your treatment decisions based on your specific circumstances. I went off methadone cold turkey from 65 mg and it was hell..in my opinion there is little difference in w/d from 10mg to 65 mg in terms of w/d..others may disagree but I don't care. methadone has a very long 1/2 life..meaning it build itself up in your system.. Both methadone abuse and lawfully prescribed use will eventually lead to dependence.

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Retrieved November 26, 2015, from Abadinsky, H., & Abadinsky, H. (2014). Prolonged use or abuse may produce one or more of the following side effects: Tolerance that compels users to take more of the drug to experience the same degree of high Physical dependence that causes withdrawal symptoms like stomach cramps, diarrhea, and bone and muscle pain Addiction that may stem from physical dependence Lung and respiratory problems Cardiac problems Neurological effects like decline in cognitive functionality Menstrual problems in women Continued use of methadone still keeps a user dependent on opioids. Also helps with my periods which have also become intolerable. Cytochrome P450 enzymes, primarily CYP3A4, CYP2B6, CYP2C19, and to a lesser extent CYP2C9 and CYP2D6, are responsible for conversion of methadone to EDDP and other inactive metabolites, which are excreted mainly in the urine. For this reason, the drug should never be taken casually.

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Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). If it is almost time for your next dose, skip the one you missed and move on.

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LOL. (Sorry, had to throw in some comic relief here. See also: Side effects (in more detail) What other drugs will affect methadone? Gender The pharmacokinetics of methadone have not been evaluated for gender specificity. Methadone is metabolized by hepatic pathways, therefore patients with liver impairment may be at risk of accumulating methadone after multiple dosing. This is not a complete list of the side effects associated with Dolophine (methadone). Methadone is prescribed for pain and also drug addiction detoxification. Get a more detailed answer › 1 doctor agreed: 20 20 My specialist wants me to change from oxycontin to methadone.

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