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To date, methadone maintenance therapy has been the most systematically studied and most successful,[citation needed] and most politically polarizing,[citation needed] of any pharmacotherapy for the treatment of people with drug addiction. Cytochrome P450 Inducers Methadone-maintained patients beginning treatment with CYP3A4 inducers should be monitored for evidence of withdrawal effects and methadone dose should be adjusted accordingly. High quality, well-managed clinics will carefully monitor their patients during induction and work with them to get them to a comfortable dosage level as soon as possible, but without taking unnecessary risks. When using naloxone, the naloxone will be quickly eliminated and the withdrawal will be short lived.

The most frequently observed adverse reactions include lightheadedness, dizziness, sedation, nausea, vomiting, and sweating. Similar reactions thus far have not been reported with methadone.

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Comments: -Use lower dose for patients whose tolerance is expected to be low at treatment entry. -Patients who have not taken opioids for more than 5 days may no longer be tolerant; initial doses should not be based on previous treatment episodes. -Patients receiving methadone maintenance for opioid dependence cannot be expected to derive analgesia from their methadone; if acute pain occurs and requires treatment, these patients may require higher and/or more frequent doses than non-tolerant patients due to the opioid tolerance induced by methadone. -During pregnancy, an increase in dose or a decrease in dosing interval may be required due to altered kinetics. It is critical to understand the pharmacokinetics of methadone and to exercise vigilance during treatment initiation and dose titration (see DOSAGE AND ADMINISTRATION). Many substances can also induce, inhibit or compete with these enzymes further affecting (sometimes dangerously) methadone half-life. As long as you are only taking the methadone and nothing else drug wise your baby will be fine. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Miracles will happened if you are patient and use several month's to reduce doses.

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It was like a game to them," Dave's daughter, Melissa Fisk, 32, told The Press. 5 mg to 10 mg IV every 8 to 12 hours Maintenance dose: Slowly titrate to effect; more frequent administration may be required to maintain adequate analgesia during initiation, however, extreme caution is necessary to avoid overdosing. These are not normal side effects, and the presence of any one of these reactions should prompt an immediate call to a doctor. Read More Hi, I just want to echo what mrmichael said about methadone clinics, that some are good and some not as good. National Center for Health Statistics,[40] as well as a 2006 series in the Charleston Gazette (West Virginia),[41] medical examiners listed methadone as contributing to 3,849 deaths in 2004.

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When methadone is used as part of a treatment program for drug addiction or detoxification, your doctor may recommend that this medicine be given to you by a family member or other caregiver. Adverse effects[edit] Addiction experts in psychiatry, chemistry, pharmacology, forensic science, epidemiology, and the police and legal services engaged in delphic analysis regarding 20 popular recreational drugs. To date, methadone maintenance therapy has been the most systematically studied and most successful,[citation needed] and most politically polarizing,[citation needed] of any pharmacotherapy for the treatment of people with drug addiction. Presence of flecks is not usually important either. Never use this medicine in larger amounts, or for longer than prescribed. I also breast fed him and that helps the baby as well. If you come across any problems or wish to ask a question, please do not hesitate to contact our Support service using the contact us form.My regular clinic gives Methadose tablets dissolved in water with a little bit of juice. Infants born to mothers physically dependent on opioids may also be physically dependent and may exhibit respiratory difficulties and withdrawal symptoms (see PRECAUTIONS : Pregnancy, Labor and Delivery). It can vary depending on how the pharmacy mixes the methadone solution but there are usually 10mg of methadone per ml. These factors, combined with sedation, have been linked to the causation of extensive dental damage.[31][32] Overdose[edit] Most people who have overdosed on methadone may show some of the following symptoms: Miosis (constricted pupils)[33] Vomiting[34] Hypoventilation (breathing that is too slow/shallow)[33] Drowsiness,[33] sleepiness, disorientation, sedation, unresponsiveness Skin that is cool, clammy (damp), and pale[33] Limp muscles,[33] trouble staying awake, nausea Unconsciousness[33] and coma[33] Death[34] The respiratory depression of an overdose can be treated with naloxone.[30] Naloxone is preferred to the newer, longer acting antagonist naltrexone. Please check with him/her/them before proceeding.

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