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I was on it for 5 years at 150mg for maintenance therapy. Methadone helps these people stop taking the medications or to help them avoid restarting the medications. If you are experiencing unexplained weight gain, with no changes in diet or activity level, you may want to contact your health care provider. Everyone reacts/responds differently to medication and to addiction, so your doctor and answer your question to this best. Interactions With Alcohol And Drugs of Abuse Methadone may be expected to have additive effects when used in conjunction with alcohol, other opioids, or illicit drugs that cause central nervous system depression.

It was not until studies performed at the Rockefeller University in New York City by Professor Vincent Dole, along with Marie Nyswander and Mary Jeanne Kreek, that methadone was systematically studied as a potential substitution therapy. Cost[edit] Methadone maintenance treatment[edit] Methadone maintenance clinics in the US charge anywhere from $5 to $400 per week, which may be covered by private insurance or Medicaid.[citation needed] In Germany, methadone maintenance treatment (MMT) is fully covered by all public and private insurance plans. Other reported clinical experience has not identified differences in responses between elderly and younger patients. If this is the case, we recommend disabling these add-ons.

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Methadone is used as a pain reliever and as part of drug addiction detoxification and maintenance programs. An addiction to any substance can have an incredibly dangerous impact on a person, and addiction to methadone is no different.

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For pain, again no one starts out on that high of a dose, but will be prescribed a smaller dose to keep chronic pain under control over a period of time. The analgesic activity is shorter than the pharmacological half-life; dosing for pain control usually requires multiple doses per day normally dividing daily dosage for administration at 8 hour intervals.[52] The main metabolic pathway involves N-demethylation by CYP3A4 in the liver and intestine to give 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP).[1][53] This inactive product, as well as the inactive 2-ethyl-5-methyl-3,3- diphenyl-1-pyrroline (EMDP), produced by a second N-demethylation, are detectable in the urine of those taking methadone.

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Patients who use other substances of abuse should not breastfeed. Most cases involve patients being treated for pain with large, multiple daily doses of methadone, although cases have been reported in patients receiving doses commonly used for maintenance treatment of opioid addiction. Besides weakened respiratory and cardiac functions, methadone users may suffer from the following long-term medical conditions or disorders affecting various other major organs and systems of the body: Whole Body: headaches, weakness, and water retention Central Nervous System: confusion, disorientation, euphoria, depression and listlessness, sleep disturbances Endocrinal System: hypogonadism or low testosterone level, a condition that impairs growth and development in males during puberty Gastrointestinal System: abdominal pain, constipation, dry mouth Metabolic System: low potassium or magnesium levels, weight gain Blood: low platelet count that causes the blood to clot slowly after an injury, bruising, internal bleeding Kidneys: urine retention, difficulty urinating Reproductive System: reduced sexual drive, reduced sperm production, abnormal absence of menstruation in women Skin: rashes, hives, severe itching that can lead to sores Not all methadone users exhibit the adverse effects of the drugs to the same degree. Pharmacokinetics In Special Populations Pregnancy The disposition of oral methadone has been studied in approximately 30 pregnant patients in the second and third trimesters. These side effects may go away during treatment as your body adjusts to the medicine. Long-term use of opioid medication may affect fertility (ability to have children) in men or women. Drugs that block narcotic (opioid) receptors including pentazocine (Talwin), nalbuphine (Nubain), naloxone (Narcan), butorphanol (Stadol) and buprenorphine (Subutex) can lead to withdrawal symptoms. But according to the Center for Substance Abuse Research at the University of Maryland, the long-term effects of methadone and especially its withdrawal symptoms are less harsh than those caused by heroin abuse. Narcotic (opioid) medication can interact with many other drugs and cause dangerous side effects or death. Is methadone better? ?: I can't tell you because i don't know you but even if i knew you, it depends. If this is the case, youʼll just need to enter the CAPTCHA code once, and weʼll be able to distinguish between you and the other users on your IP address. They are there to keep you on this drug that rots away at your mind and body, and they do it well. Any help or tips are truly appreciated! ## Hi Traveler, I'm not sure I understand the concern about your friend going around family doesn't know she is prescribed methadone.

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